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Pluba Understudy
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http://search.petfinder.com/petnote/displaypet.cgi?petid=8839040
What a sad little creature this is and why would anyone want to perpetuate this condition? Merle as a pigment reducing gene can cause these types of defects because pigment development occurs during the formation of the neural crest.
Posts: 266 | Registered: Tue March 23 2004
Good Pluba
Posted
Wow, what a sad little creature YOU are Not-to-be-taken-Sirius-ly ... 
Funny you should bring this up because just the other day I watched an interesting vet program that had a Golden Retriever with a terrible problem and deformities to his genitalia and it was amazing the way they put that little dog's private parts together. It was very tricky surgery but they basically reconstructed that dog's genitals.
Now of course this Golden Retriever was NOT a merle.
The FACT IS that YES, both merle AND NON-MERLE dogs have BIRTH DEFECTS. Then again SO DO PEOPLE. Hardly related to a single copy of the merle gene. It's simply a SAD FACT OF LIFE. 
Once again, poor Sirius is grasping at straws and has proven NOTHING. 
HOW SAD IT MUST BE TO BE ONE OF THESE ANTI-MERLE BIGOTS TRYING SO HARD TO CONVINCE PEOPLE OF SOMETHING THAT JUST AIN'T SO! 
________________________________
www.loveschihuahuas.com
HOME OF CHIELLE CHIHUAHUAS
"There's NO Substitute for QUALITY!"
Posts: 3789 | Location (City, State): SoCA | Registered: Sun January 11 2004
Pluba Understudy
Posted
You people on this board certainly have a problem with differentiating between actual documentation and hearsay.
I saw a documentary and it said that elephants have green spots and purple ears when viewed at dusk...
I have no real proof but I just wanted to say that...
Posts: 266 | Registered: Tue March 23 2004
Pluba Understudy
Posted
The merle phenotype of the dog is a pattern of pigmentation associated with a wide range of developmental defects. A whole genome scan for merle by using 41 Shetland Sheepdogs showed LD with FH2537 on CFA10. No genes previously implicated in WS (PAX3, MITF, SOX10, EDNRB, and EDN3) map to this region. However, another gene important in pigmentation, SILV, is located {approx}0.2 Mb from this marker. The SILV protein appears to be necessary for the formation of the fibril matrix upon which melanin intermediates are deposited late in melanosome maturation (24). Other studies have shown that SILV may also participate in melanin biosynthesis by accelerating the conversion of 5,6-dihydroxyindole-2-carboxylic acid to melanin (34, 35).
http://www.pnas.org/cgi/content/full/103/5/1376?maxtosh...0&resourcetype=HWCIT
Posts: 266 | Registered: Tue March 23 2004
Good Pluba
Posted
quote:Originally posted by Sirius:
You people on this board certainly have a problem with differentiating between actual documentation and hearsay.
I saw a documentary and it said that elephants have green spots and purple ears when viewed at dusk...
I have no real proof but I just wanted to say that...
OMG - this is too riiiich! 
Kind of like even tho they have NO proof or documentation of harm to the Chihuahua due to a single copy of the merle gene, we are supposed to believe a handful of narrow minded anti-merle bigots that merle is "evil" just because they "say so"!
Oh yeah and don't forget only merle dogs have birth defects -- and it must be the merle gene that causes birth defects in people too I bet!!
PALEEZ ...
________________________________
www.loveschihuahuas.com
HOME OF CHIELLE CHIHUAHUAS
"There's NO Substitute for QUALITY!"
Posts: 3789 | Location (City, State): SoCA | Registered: Sun January 11 2004
Newba Pluba
Posted
quote:Originally posted by Sirius:
The merle phenotype of the dog is a pattern of pigmentation associated with a wide range of developmental defects. A whole genome scan for merle by using 41 Shetland Sheepdogs showed LD with FH2537 on CFA10. No genes previously implicated in WS (PAX3, MITF, SOX10, EDNRB, and EDN3) map to this region. However, another gene important in pigmentation, SILV, is located {approx}0.2 Mb from this marker. The SILV protein appears to be necessary for the formation of the fibril matrix upon which melanin intermediates are deposited late in melanosome maturation (24). Other studies have shown that SILV may also participate in melanin biosynthesis by accelerating the conversion of 5,6-dihydroxyindole-2-carboxylic acid to melanin (34, 35).
http://www.pnas.org/cgi/content/full/103/5/1376?maxtosh...0&resourcetype=HWCIT
MY,, I AM TRULY SURPRISED AT HOW WELL YOU CAN COPY THAT INFO - LIKE A REAL PRO, NO LESS! SO.........WHEN IS THE MERLE SHELTIE GOING TO BE BANNED? AND THE MERLE COLLIE? AND THE MERLE CORGI? JUST THOUGHT MAYBE YOU COULD SHARE THAT INFO WITH US SEEING AS HOW WELL INFORMED YOU LIKE TO MAKE YOURSELF APPEAR. DON'T KEEP US IN SUSPENSE, PLEASE - OUT WITH IT!
MAGGIE MAY
Posts: 142 | Registered: Sun July 15 2007
Newba Pluba
Posted
quote:Originally posted by Sirius:
http://search.petfinder.com/petnote/displaypet.cgi?petid=8839040
What a sad little creature this is and why would anyone want to perpetuate this condition? Merle as a pigment reducing gene can cause these types of defects because pigment development occurs during the formation of the neural crest.
SO IN SPITE OF ALL YOU HAVE SUPPOSEDLY LEARNED ABOUT THE MERLE GENE, YOU ARE NOW BLAMING THE LACK OF GENITAL DEVELOPMENT ON IT TOO? YOU ARE WAY OFF BASE, AND OF COURSE, I DON'T EXPECT YOU TO AGREE, BUT THIS PRESENTS MORE AS A CONGENITAL DEFECT AS OPPOSED TO A MERLE LINKED DEFECT AND THAT CAN HAPPEN IN ANY BREED AS YOU SHOULD KNOW - OR APPARENTLY NOT.
MAGGIE MAY
Posts: 142 | Registered: Sun July 15 2007
Pluba Understudy
Posted
My goodness ratlady if I did not know better I would swear you posed for this painting! You never listen or read anything above an elementary level do you? Lots of you do not read well I see...
Posts: 266 | Registered: Tue March 23 2004
Newba Pluba
Posted
quote:Originally posted by Sirius:
What a sad little creature this is and why would anyone want to perpetuate this condition? Merle as a pigment reducing gene can cause these types of defects because pigment development occurs during the formation of the neural crest.
http://wcbstv.com/seenon/local_story_136161826.html
WHAT SAD LITTLE CREATURES....WHY WOULD ANYONE WANT TO PERPETUATE THESE CONDITIONS? BLACK AND TAN AND/OR FAWNS CAN HAVE THESE DEFECTS.
Posts: 221 | Registered: Sat October 22 2005
Good Pluba
Posted
quote:Originally posted by GEORGE1948:
quote:Originally posted by Sirius:
What a sad little creature this is and why would anyone want to perpetuate this condition? Merle as a pigment reducing gene can cause these types of defects because pigment development occurs during the formation of the neural crest.
http://wcbstv.com/seenon/local_story_136161826.html
WHAT SAD LITTLE CREATURES....WHY WOULD ANYONE WANT TO PERPETUATE THESE CONDITIONS? BLACK AND TAN AND/OR FAWNS CAN HAVE THESE DEFECTS.
You beat me to it George!!
I was thinking of this very same story when I read the nonsense post from ****.
Posts: 1719 | Registered: Mon January 24 2005
Newba Pluba
Posted
quote:Originally posted by GEORGE1948:
quote:Originally posted by Sirius:
What a sad little creature this is and why would anyone want to perpetuate this condition? Merle as a pigment reducing gene can cause these types of defects because pigment development occurs during the formation of the neural crest.
http://wcbstv.com/seenon/local_story_136161826.html
WHAT SAD LITTLE CREATURES....WHY WOULD ANYONE WANT TO PERPETUATE THESE CONDITIONS? BLACK AND TAN AND/OR FAWNS CAN HAVE THESE DEFECTS.
This makes me ill - but lo & behold! They are NOT merles! They are black & Tan! I am having a case of apoplexy here - isn't it true that things like this NEVER HAPPEN in dogs that aren't merles???????????????????????????? RIGHT.I wonder what all the holier-than-thou breeders of regular colors have to say about that? BYB's or not - something is very wrong here to have 3 of 5 with no front legs. Looks to me like hidden problems of regularly colored Chi's are coming to the forefront. But remember folks - that can only happen in merles! As if......................
Maggie May
Posts: 142 | Registered: Sun July 15 2007
Very Good Pluba
Posted
quote:Originally posted by Sirius:
I saw a documentary and it said that elephants have green spots and purple ears when viewed at dusk...
I have no real proof but I just wanted to say that...
I thought they were pink... Well, maybe that's just me hehehe.
Posts: 4432 | Registered: Fri April 02 2004
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Back to Pluba.com Pluba Forums For the Critters... Breeders Corner... This never happens in merles REALLY?
Pluba Forums For the Critters... Breeders Corner... This never happens in merles REALLY?|
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Pluba Understudy |
http://search.petfinder.com/petnote/displaypet.cgi?petid=8839040
What a sad little creature this is and why would anyone want to perpetuate this condition? Merle as a pigment reducing gene can cause these types of defects because pigment development occurs during the formation of the neural crest. |
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Good Pluba |
Wow, what a sad little creature YOU are Not-to-be-taken-Sirius-ly ...
Funny you should bring this up because just the other day I watched an interesting vet program that had a Golden Retriever with a terrible problem and deformities to his genitalia and it was amazing the way they put that little dog's private parts together. It was very tricky surgery but they basically reconstructed that dog's genitals. Now of course this Golden Retriever was NOT a merle. The FACT IS that YES, both merle AND NON-MERLE dogs have BIRTH DEFECTS. Then again SO DO PEOPLE. Hardly related to a single copy of the merle gene. It's simply a SAD FACT OF LIFE. Once again, poor Sirius is grasping at straws and has proven NOTHING. HOW SAD IT MUST BE TO BE ONE OF THESE ANTI-MERLE BIGOTS TRYING SO HARD TO CONVINCE PEOPLE OF SOMETHING THAT JUST AIN'T SO! ________________________________ www.loveschihuahuas.com HOME OF CHIELLE CHIHUAHUAS "There's NO Substitute for QUALITY!" |
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Pluba Understudy |
You people on this board certainly have a problem with differentiating between actual documentation and hearsay.
I saw a documentary and it said that elephants have green spots and purple ears when viewed at dusk... I have no real proof but I just wanted to say that... |
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Pluba Understudy |
The merle phenotype of the dog is a pattern of pigmentation associated with a wide range of developmental defects. A whole genome scan for merle by using 41 Shetland Sheepdogs showed LD with FH2537 on CFA10. No genes previously implicated in WS (PAX3, MITF, SOX10, EDNRB, and EDN3) map to this region. However, another gene important in pigmentation, SILV, is located {approx}0.2 Mb from this marker. The SILV protein appears to be necessary for the formation of the fibril matrix upon which melanin intermediates are deposited late in melanosome maturation (24). Other studies have shown that SILV may also participate in melanin biosynthesis by accelerating the conversion of 5,6-dihydroxyindole-2-carboxylic acid to melanin (34, 35).
http://www.pnas.org/cgi/content/full/103/5/1376?maxtosh...0&resourcetype=HWCIT |
|||
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Good Pluba |
OMG - this is too riiiich! Kind of like even tho they have NO proof or documentation of harm to the Chihuahua due to a single copy of the merle gene, we are supposed to believe a handful of narrow minded anti-merle bigots that merle is "evil" just because they "say so"! Oh yeah and don't forget only merle dogs have birth defects -- and it must be the merle gene that causes birth defects in people too I bet!! PALEEZ ... ________________________________ www.loveschihuahuas.com HOME OF CHIELLE CHIHUAHUAS "There's NO Substitute for QUALITY!" |
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Newba Pluba |
MY,, I AM TRULY SURPRISED AT HOW WELL YOU CAN COPY THAT INFO - LIKE A REAL PRO, NO LESS! SO.........WHEN IS THE MERLE SHELTIE GOING TO BE BANNED? AND THE MERLE COLLIE? AND THE MERLE CORGI? JUST THOUGHT MAYBE YOU COULD SHARE THAT INFO WITH US SEEING AS HOW WELL INFORMED YOU LIKE TO MAKE YOURSELF APPEAR. DON'T KEEP US IN SUSPENSE, PLEASE - OUT WITH IT! MAGGIE MAY |
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Newba Pluba |
SO IN SPITE OF ALL YOU HAVE SUPPOSEDLY LEARNED ABOUT THE MERLE GENE, YOU ARE NOW BLAMING THE LACK OF GENITAL DEVELOPMENT ON IT TOO? YOU ARE WAY OFF BASE, AND OF COURSE, I DON'T EXPECT YOU TO AGREE, BUT THIS PRESENTS MORE AS A CONGENITAL DEFECT AS OPPOSED TO A MERLE LINKED DEFECT AND THAT CAN HAPPEN IN ANY BREED AS YOU SHOULD KNOW - OR APPARENTLY NOT. MAGGIE MAY |
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Pluba Understudy |
My goodness ratlady if I did not know better I would swear you posed for this painting! You never listen or read anything above an elementary level do you? Lots of you do not read well I see...
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Newba Pluba |
http://wcbstv.com/seenon/local_story_136161826.html WHAT SAD LITTLE CREATURES....WHY WOULD ANYONE WANT TO PERPETUATE THESE CONDITIONS? BLACK AND TAN AND/OR FAWNS CAN HAVE THESE DEFECTS. |
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Good Pluba |
You beat me to it George!! I was thinking of this very same story when I read the nonsense post from ****. |
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Newba Pluba |
This makes me ill - but lo & behold! They are NOT merles! They are black & Tan! I am having a case of apoplexy here - isn't it true that things like this NEVER HAPPEN in dogs that aren't merles???????????????????????????? RIGHT.I wonder what all the holier-than-thou breeders of regular colors have to say about that? BYB's or not - something is very wrong here to have 3 of 5 with no front legs. Looks to me like hidden problems of regularly colored Chi's are coming to the forefront. But remember folks - that can only happen in merles! As if...................... Maggie May |
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Very Good Pluba |
I thought they were pink... Well, maybe that's just me hehehe. |
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Back to Pluba.com Pluba Forums For the Critters... Breeders Corner... This never happens in merles REALLY?
Pluba Forums For the Critters... Breeders Corner... This never happens in merles REALLY?© Copyright Pluba.com 2001-2007.8